Mechanistic Insights into Phosphoprotein-Binding FHA Domains
نویسندگان
چکیده
منابع مشابه
The FHA domain mediates phosphoprotein interactions.
The forkhead-associated (FHA) domain is a phosphopeptide-binding domain first identified in a group of forkhead transcription factors but is present in a wide variety of proteins from both prokaryotes and eukaryotes. In yeast and human, many proteins containing an FHA domain are found in the nucleus and involved in DNA repair, cell cycle arrest, or pre-mRNA processing. In plants, the FHA domain...
متن کاملMechanistic Insights into Hsp104 Potentiation.
Potentiated variants of Hsp104, a protein disaggregase from yeast, can dissolve protein aggregates connected to neurodegenerative diseases such as Parkinson disease and amyotrophic lateral sclerosis. However, the mechanisms underlying Hsp104 potentiation remain incompletely defined. Here, we establish that 2-3 subunits of the Hsp104 hexamer must bear an A503V potentiating mutation to elicit enh...
متن کاملInsights into How Nucleotide-Binding Domains Power ABC Transport
The mechanism by which nucleotide-binding domains (NBDs) of ABC transporters power the transport of substrates across cell membranes is currently unclear. Here we report the crystal structure of an NBD, FbpC, from the Neisseria gonorrhoeae ferric iron uptake transporter with an unusual and substantial domain swap in the C-terminal regulatory domain. This entanglement suggests that FbpC is unabl...
متن کاملStructural and mechanistic insights into cGMP signaling
Background The second messenger cGMP plays a central role in regulating bodily functions, e.g. in the cardiovascular and nervous systems. cGMP is formed by guanylyl cyclases (GC), activates target proteins, and is finally hydrolyzed by cyclic nucleotide phosphodiesterases (PDE). PDEs and GCs are widely used as drug targets, spurring interest in mechanistic and structural insights into their reg...
متن کاملRecent mechanistic insights into eukaryotic ribosomes.
Ribosomes are supramolecular ribonucleoprotein particles that synthesize proteins in all cells. Protein synthesis proceeds through four major phases: initiation, elongation, termination, and ribosome recycling. In each phase, a number of phase-specific translation factors cooperate with the ribosome. Whereas elongation in prokaryotes and eukaryotes involve similar factors and proceed by similar...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Accounts of Chemical Research
سال: 2008
ISSN: 0001-4842,1520-4898
DOI: 10.1021/ar700148u